Pharmacodynamics of antimicrobial drugs.
نویسنده
چکیده
Knowledge of the antimicrobial pharmacodynamic characteristics of a drug (inhibition of growth, rate and extent of bactericidal action, and postantibiotic effect) provides a more rational basis for determination of optimal dosing regimens in terms of the dose and the dosing interval. This article reviews concepts of antimicrobial pharmacodynamics, the effect of pharmacodynamics on the emergence of resistant bacterial subpopulations, and the development of pharmacodynamic breakpoints for use in the design of trials of these drugs and in treatment of infected patients.
منابع مشابه
Pk-pd Integration and Pk-pd Modelling: Alternatives to Dose Titration Studies for Selecting Optimal Dosage Schedules of Antimicrobial Drugs
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عنوان ژورنال:
- Infectious disease clinics of North America
دوره 18 3 شماره
صفحات -
تاریخ انتشار 2004